DMP1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of DMP1.
Immunogen
A synthetic peptide corresponding to human DMP1.
Sequence
C-ENSEQANTQDSG
Host
Goat
Theoretical MW (kDa)
55.8, 54.1
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:4000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
DMP1 polyclonal antibody (Cat # PAB11518) (1 ug/mL) staining of human kidney lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — DMP1
Entrez GeneID
1758Protein Accession#
NP_004398.1;NP_001073380.1Gene Name
DMP1
Gene Alias
DMP-1
Gene Description
dentin matrix acidic phosphoprotein 1
Omim ID
600980Gene Ontology
HyperlinkGene Summary
Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
dentin matrix protein 1
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Interactome
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Disease
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Publication Reference
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Dentin matrix protein 1 (DMP1): new and important roles for biomineralization and phosphate homeostasis.
Qin C, D'Souza R, Feng JQ.
Journal of Dental Research 2007 Dec; 86(12):1134.
Application:IHC, Mouse, Mouse mineralized tissues.
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Dentin matrix protein 1 (DMP1): new and important roles for biomineralization and phosphate homeostasis.
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