CHRNB1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
CHRNB1 polyclonal antibody (Cat # PAB11510) (1 ug/mL) staining of human cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CHRNB1.
Immunogen
A synthetic peptide corresponding to human CHRNB1.
Sequence
C-QEQEDHDALKED
Host
Goat
Theoretical MW (kDa)
56.7
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:1000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
CHRNB1 polyclonal antibody (Cat # PAB11510) (1 ug/mL) staining of human cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CHRNB1
Entrez GeneID
1140Protein Accession#
NP_000738.2Gene Name
CHRNB1
Gene Alias
ACHRB, CHRNB, CMS1D, CMS2A, SCCMS
Gene Description
cholinergic receptor, nicotinic, beta 1 (muscle)
Gene Ontology
HyperlinkGene Summary
The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome. [provided by RefSeq
Other Designations
cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)|nicotinic acetylcholine receptor beta 1 subunit
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Interactome
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Disease
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Publication Reference
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Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence.
Lou XY, Ma JZ, Payne TJ, Beuten J, Crew KM, Li MD.
Journal of Human Genetics 2006 Oct; 120(3):381.
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Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence.
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