CACNA1C polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CACNA1C.
Immunogen
A synthetic peptide corresponding to human CACNA1C.
Sequence
C-RARGRPSEEELQD
Host
Goat
Theoretical MW (kDa)
240
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (0.5-1.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
CACNA1C polyclonal antibody (Cat # PAB11506) (0.5 ug/mL) staining of human heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CACNA1C
Entrez GeneID
775Protein Accession#
NP_000710.5.Gene Name
CACNA1C
Gene Alias
CACH2, CACN2, CACNL1A1, CCHL1A1, CaV1.2, MGC120730, TS
Gene Description
calcium channel, voltage-dependent, L type, alpha 1C subunit
Gene Ontology
HyperlinkGene Summary
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. [provided by RefSeq
Other Designations
DHPR, alpha-1 subunit|calcium channel, L type, alpha 1 polypeptide, isoform 1, cardic muscle|calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit|voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*|voltage-gated c
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Interactome
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Pathway
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Disease
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Publication Reference
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Calpastatin binds to a calmodulin-binding site of cardiac Cav1.2 Ca2+ channels.
Saud ZA, Minobe E, Wang WY, Han DY, Horiuchi M, Hao LY, Kameyama M.
Biochemical and Biophysical Research Communications 2007 Dec; 364(2):372.
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Calpastatin binds to a calmodulin-binding site of cardiac Cav1.2 Ca2+ channels.
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