GABRA4 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
GABRA4 polyclonal antibody (Cat # PAB11468) (0.1 ug/mL) staining of human frontal cortex lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
GABRA4 polyclonal antibody (Cat # PAB11468) (2.5 ug/mL) staining of paraffin embedded human cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of GABRA4.
Immunogen
A synthetic peptide corresponding to human GABRA4.
Sequence
C-EKAKRKTSKPPQE
Host
Goat
Theoretical MW (kDa)
61.6
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (0.1-0.3 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
GABRA4 polyclonal antibody (Cat # PAB11468) (0.1 ug/mL) staining of human frontal cortex lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
GABRA4 polyclonal antibody (Cat # PAB11468) (2.5 ug/mL) staining of paraffin embedded human cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — GABRA4
Entrez GeneID
2557Protein Accession#
NP_000800.2Gene Name
GABRA4
Gene Alias
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Gene Description
gamma-aminobutyric acid (GABA) A receptor, alpha 4
Omim ID
137141Gene Ontology
HyperlinkGene Summary
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq
Other Designations
gamma-aminobutyric acid A receptor, alpha 4
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Interactome
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Pathway
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Disease
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Publication Reference
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Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism.
Ma DQ, Whitehead PL, Menold MM, Martin ER, Ashley-Koch AE, Mei H, Ritchie MD, Delong GR, Abramson RK, Wright HH, Cuccaro ML, Hussman JP, Gilbert JR, Pericak-Vance MA.
American Journal of Human Genetics 2005 Sep; 77(3):377.
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Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism.
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