ANXA1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
ANXA1 polyclonal antibody (Cat # PAB11466)(0.5 ug/mL) staining of rat spleen lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Western Blot (Cell lysate)
ANXA1 polyclonal antibody (Cat # PAB11466) (0.5 ug/mL) staining of A-431 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ANXA1.
Immunogen
A synthetic peptide corresponding to human ANXA1.
Sequence
CQAILDETKGDYEK
Host
Goat
Theoretical MW (kDa)
38.7
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western Blot (0.5-1.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
ANXA1 polyclonal antibody (Cat # PAB11466)(0.5 ug/mL) staining of rat spleen lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Western Blot (Cell lysate)
ANXA1 polyclonal antibody (Cat # PAB11466) (0.5 ug/mL) staining of A-431 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ANXA1
Entrez GeneID
301Protein Accession#
NP_000691.1Gene Name
ANXA1
Gene Alias
ANX1, LPC1
Gene Description
annexin A1
Omim ID
151690Gene Ontology
HyperlinkGene Summary
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq
Other Designations
OTTHUMP00000021474|OTTHUMP00000021475|annexin I|annexin I (lipocortin I)|lipocortin I
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Interactome
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Disease
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Publication Reference
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Macrophage surface expression of annexins I and II in the phagocytosis of apoptotic lymphocytes.
Fan X, Krahling S, Smith D, Williamson P, Schlegel RA.
Molecular Biology of the Cell 2004 Jun; 15(6):2863.
Application：Flow Cyt, WB, Human, Mouse, Jurkat, NIH/3T3, U-937 cells.
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Loss of annexin 1 correlates with early onset of tumorigenesis in esophageal and prostate carcinoma.
Paweletz CP, Ornstein DK, Roth MJ, Bichsel VE, Gillespie JW, Calvert VS, Vocke CD, Hewitt SM, Duray PH, Herring J, Wang QH, Hu N, Linehan WM, Taylor PR, Liotta LA, Emmert-Buck MR, Petricoin EF 3rd.
Cancer Research 2000 Nov; 60(22):6293.
Application：IHC-P, WB-Ti, Human, Esophageal cancer epithelium, Prostate cancer epithelium.
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Macrophage surface expression of annexins I and II in the phagocytosis of apoptotic lymphocytes.
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