DES polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of DES.
Immunogen
A synthetic peptide corresponding to C-terminus of human DES.
Sequence
C-RDGEVVSEATQQQHE
Host
Goat
Theoretical MW (kDa)
53.5
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:2000)
Western Blot (0.1-0.3 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3-6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
DES polyclonal antibody (Cat # PAB11453) (0.2 ug/mL) staining of human skeletal muscle lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
DES polyclonal antibody (Cat # PAB11453)(3.8 ug/mL) staining of paraffin embedded human prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — DES
Entrez GeneID
1674Protein Accession#
NP_001918.3Gene Name
DES
Gene Alias
CMD1I, CSM1, CSM2, FLJ12025, FLJ39719, FLJ41013, FLJ41793
Gene Description
desmin
Gene Ontology
HyperlinkGene Summary
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq
Other Designations
OTTHUMP00000064865|intermediate filament protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes.
Nicolas J. Pillon, Jonathon A. B. Smith, Petter S. Alm, Alexander V. Chibalin, Julia Alhusen, Erik Arner, Piero Carninci, Tomas Fritz, Julia Otten, Tommy Olsson, Sophie van Doorslaer de ten Ryen, Louise Deldicque, Kenneth Caidahl, Harriet Wallberg-Henriksson, Anna Krook, Juleen R. Zierath.
Science Advances 2022 Sep; 8(36):eabo3192.
Application:IF, Human, Human myofibers.
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Caspase proteolysis of desmin produces a dominant-negative inhibitor of intermediate filaments and promotes apoptosis.
Chen F, Chang R, Trivedi M, Capetanaki Y, Cryns VL.
The Journal of Biological Chemistry 2003 Feb; 278(9):6848.
Application:WB-Ce, WB-Tr, Human, Mouse, HL-1, MCF-7 cells.
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Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes.
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