PARP3 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PARP3.
Immunogen
A synthetic peptide corresponding to human PARP3.
Sequence
YEDYNCTLNQTNIEN
Host
Goat
Theoretical MW (kDa)
60.8, 60.1
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — PARP3
Entrez GeneID
10039Protein Accession#
NP_001003931.2;NP_001003935.2Gene Name
PARP3
Gene Alias
ADPRT3, ADPRTL2, ADPRTL3, IRT1, hPARP-3, pADPRT-3
Gene Description
poly (ADP-ribose) polymerase family, member 3
Omim ID
607726Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 2|ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3|NAD+ ADP-ribosyltransferase 3|poly(ADP-ribose) polymerase 3|poly(ADP-ribose) synthetase-3
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Interactome
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Pathway
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Disease
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Publication Reference
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PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery.
Rouleau M, McDonald D, Gagne P, Ouellet ME, Droit A, Hunter JM, Dutertre S, Prigent C, Hendzel MJ, Poirier GG.
Journal of Cellular Biochemistry 2007 Feb; 100(2):385.
Application：IF, Human, Monkey, COS-7, HeLa cells.
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PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery.
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