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Last updated: 2017/12/10
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SPHK1 polyclonal antibody

  • Catalog # : PAB11412
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of SPHK1.
  • Immunogen:
  • A synthetic peptide corresponding to human SPHK1.
  • Sequence:
  • C-DVDLESEKYRRLGE
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 43.9, 51.1
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • ELISA (1:16000)
    Western Blot (2-3 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • SPHK1 polyclonal antibody (Cat # PAB11412) (2 ug/mL) staining of human peripheral blood mononucleocyte (PBMCs) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • Immunoprecipitation
  • ELISA
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunoprecipitation
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 8877
  • Protein Accession#:
  • NP_068807.2;NP_892010.1
  • Gene Name:
  • SPHK1
  • Gene Alias:
  • SPHK
  • Gene Description:
  • sphingosine kinase 1
  • Gene Summary:
  • Sphingosine-1-phosphate (SPP) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 601974). Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 173430) and serum.[supplied by OMIM
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