GRIA4 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
GRIA4 polyclonal antibody (Cat # PAB11410) (0.3 ug/mL) staining of human cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
GRIA4 polyclonal antibody (Cat # PAB11410) (5 ug/mL) staining of paraffin embedded human cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of GRIA4.
Immunogen
A synthetic peptide corresponding to human GRIA4 .
Sequence
C-KKLDQREYPGSETP
Host
Goat
Theoretical MW (kDa)
101, 99.2, 71.6
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
Western blot (0.3-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
GRIA4 polyclonal antibody (Cat # PAB11410) (0.3 ug/mL) staining of human cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
GRIA4 polyclonal antibody (Cat # PAB11410) (5 ug/mL) staining of paraffin embedded human cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — GRIA4
Entrez GeneID
2893Protein Accession#
NP_000820.3;NP_001070711.1;NP_001070712.1Gene Name
GRIA4
Gene Alias
GLUR4, GLUR4C, GLURD
Gene Description
glutamate receptor, ionotrophic, AMPA 4
Omim ID
138246Gene Ontology
HyperlinkGene Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq
Other Designations
AMPA-selective glutamate receptor 4|glutamate receptor 4
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Interactome
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Pathway
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Disease
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Publication Reference
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Cloning and Characterization of Glutamate Receptor Subunit 4 (GLUA4) and its Alternatively Spliced Isoforms in Turtle Brain.
Sabirzhanov B, Keifer J.
Journal of Molecular Neuroscience 2011 Jul; 44(3):159.
Application：WB-Tr, Human, SH-SY5Y cells.
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Biophysical model of AMPA receptor trafficking and its regulation during long-term potentiation/long-term depression.
Earnshaw BA, Bressloff PC.
Journal of Neuroscience 2006 Nov; 26(47):12362.
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Cloning and Characterization of Glutamate Receptor Subunit 4 (GLUA4) and its Alternatively Spliced Isoforms in Turtle Brain.
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