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Last updated: 2017/7/23
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RFX5 polyclonal antibody

  • Catalog # : PAB11300
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of RFX5.
  • Immunogen:
  • A synthetic peptide (conjugated with KLH) corresponding to amino acids 320-494 of human RFX5.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • Western Blot (1:1000)
    Gel Supershift assay (0.5-1.0 ul per assay)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • RFX5 polyclonal antibody (Cat # PAB11300) (amino acids 320-494) is shown to detect RFX5 present in Raji B cell nuclear extract lysates.
    Detection occurs using a 1 : 2,500 dilution of antibody.
  • ELISA
  • Gel Supershift Assay
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • ELISA
  • Gel Supershift Assay
  • Gene Information
  • Entrez GeneID:
  • 5993
  • Gene Name:
  • RFX5
  • Gene Alias:
  • -
  • Gene Description:
  • regulatory factor X, 5 (influences HLA class II expression)
  • Gene Summary:
  • A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000082795,OTTHUMP00000196318,regulatory factor X, 5
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