Western blot using ASAP3 polyclonal antibody (Cat # PAB11289) shows detection of ASAP3 in NIH/3T3 cells over-expressing the protein. Cell extracts (5 ug) were resolved by SDS PAGE. The membrane was probed with ASAP3 polyclonal antibody at a 1 : 10,000 dilution. Personal Communication, Vi Luan HA, CCR-NCI, Bethesda, MD.
This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq
ARF6 GTPase-activating protein,ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 1,OTTHUMP00000003268,centaurin, beta 6,development and differentiation enhancing factor-like 1,up-regulated in liver cancer 1 (UPLC1)