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Last updated: 2016/11/27
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THRB polyclonal antibody

  • Catalog # : PAB11277
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of THRB.
  • Immunogen:
  • A synthetic peptide corresponding to N-terminus of human THRB.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • ELISA (1:200000-1:220000)
    Western Blot (1:500-1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Western blot using THRB polyclonal antibody (Cat # PAB11277) shows detection of in vitro translated THRB (lane 2) and human thyroid stable cell line expressing THTRB (lane 3).
    No staining is evident in non transfected human thyroid cells (lane 1), over expressed THRA (lane 4) or HeLa stable cell line expressing THRA (lane 5).
    The band at ~62 kDa, indicated by the arrowheads, corresponds to THRB.
    Personal communication, H. Ying, NCI, Bethesda, MD.
  • Immunoprecipitation
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Immunoprecipitation
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 7068
  • Protein Accession#:
  • NP_000452.2;P10828
  • Gene Name:
  • THRB
  • Gene Alias:
  • ERBA-BETA,ERBA2,GRTH,MGC126109,MGC126110,NR1A2,PRTH,THR1,THRB1,THRB2
  • Gene Description:
  • thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
  • Gene Summary:
  • The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000161044,avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2,oncogene ERBA2,thyroid hormone receptor beta 1,thyroid hormone receptor beta isoform,thyroid hormone receptor, beta
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