TGFB1 polyclonal antibody
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More Files
- More Functions
Western Blot (Recombinant protein)
Western blot analysis using TGFB1 polyclonal antibody (Cat # PAB11274) to detect human TGFB1.
Each lane contains 250 ng of protein under non-reducing (lane 1) and reducing conditions (lane 2).
The blot was incubated with a 1:200 dilution of the antibody.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TGFB1.
Immunogen
A synthetic peptide corresponding to N-terminus of human TGFB1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:1000-1:5000)
Western Blot (1:100-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis using TGFB1 polyclonal antibody (Cat # PAB11274) to detect human TGFB1.
Each lane contains 250 ng of protein under non-reducing (lane 1) and reducing conditions (lane 2).
The blot was incubated with a 1:200 dilution of the antibody.Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
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Gene Info — TGFB1
Entrez GeneID
7040Protein Accession#
O95411;WFHU2(precursor);AAA36735(mature)Gene Name
TGFB1
Gene Alias
CED, DPD1, TGFB, TGFbeta
Gene Description
transforming growth factor, beta 1
Gene Ontology
HyperlinkGene Summary
TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA (MIM 190170) in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for this peptide. TGFB1, TGFB2 (MIM 190220), and TGFB3 (MIM 190230) all function through the same receptor signaling systems.[supplied by OMIM
Other Designations
TGF-beta 1 protein|diaphyseal dysplasia 1, progressive|transforming growth factor-beta 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-α2-deficient congenital muscular dystrophy (MDC1A).
Meinen S, Lin S, Ruegg MA.
Skeletal Muscle 2012 Sep; 2(1):18.
Application：WB-Ti, Mouse , Mouse muscle.
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Recombinant human transforming growth factor-beta 1: expression by Chinese hamster ovary cells, isolation, and characterization.
Bourdrel L, Lin CH, Lauren SL, Elmore RH, Sugarman BJ, Hu S, Westcott KR.
Protein Expression and Purification 1993 Apr; 4(2):130.
Application：WB, Recombinant protein.
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Angiotensin II type 1 receptor antagonists alleviate muscle pathology in the mouse model for laminin-α2-deficient congenital muscular dystrophy (MDC1A).
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