PPARG polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PPARG.
Immunogen
A synthetic peptide corresponding to amino acids 255 -268 of human PPARG.
Host
Rabbit
Reactivity
Dog, Guinea pig, Hamster, Human, Macaque, Mink, Mouse, Orangutan, Pig, Rabbit, Rat, Squirrel
Specificity
This affinity purified antibody is directed against human PPAR gamma protein. Expect reactivity against human (gamma1 and gamma2), mouse (gamma1 and gamma2), rat, squirrel, orangutan, duck (gamma1), macaque (gamma1-gamma7), boar (gamma1a-1d), mink, guinea pig, rabbit (gamma1 and gamma3), dog and hamster sources based on 100% homology for the immunogen sequence. No reactivity is expected against other subtypes of PPAR.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000-1:32000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — PPARG
Entrez GeneID
5468Protein Accession#
P37231(isoform2);NP_619726(isoform1);NP_056953(isoform2)Gene Name
PPARG
Gene Alias
CIMT1, NR1C3, PPARG1, PPARG2, PPARgamma
Gene Description
peroxisome proliferator-activated receptor gamma
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq
Other Designations
OTTHUMP00000185030|OTTHUMP00000185033|OTTHUMP00000185037|PPAR gamma|nuclear receptor subfamily 1 group C member 3|peroxisome proliferative activated receptor gamma|peroxisome proliferative activated receptor, gamma|peroxisome proliferator activated recept
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Interactome
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Pathway
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Disease
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Publication Reference
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Medicine. PPARs as therapeutic targets: reverse cardiology?
Plutzky J.
Science 2003 Oct; 302(5644):406.
Application:WB-Tr, Human, Cancers, Mammalian cells.
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Transcriptional repression of atherogenic inflammation: modulation by PPARdelta.
Lee CH, Chawla A, Urbiztondo N, Liao D, Boisvert WA, Evans RM, Curtiss LK.
Science 2003 Oct; 302(5644):453.
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Progress in cardiovascular biology: PPAR for the course.
Lazar MA.
Nat Med 2001 Jan; 7(1):23.
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Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation.
Chinetti G, Fruchart JC, Staels B.
Inflammation Research 2000 Oct; 49(10):497.
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Medicine. PPARs as therapeutic targets: reverse cardiology?
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