PPP2R2B polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PPP2R2B.
Immunogen
A synthetic peptide (conjugated with KLH ) corresponding to amino acids 2-14 of PPP2R2B.
Sequence
CGEEDIDTRKINNSF
Host
Rabbit
Reactivity
Bovine, Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western blot (1:500 to 1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
PPP2R2B polyclonal antibody (Cat # PAB10420) in western blot of total rat brain extract. (+) or (-) indicates present of blocking peptide or control peptide. -
Gene Info — PPP2R2B
Entrez GeneID
5521Gene Name
PPP2R2B
Gene Alias
B55-BETA, FLJ95686, MGC24888, PP2A-B55BETA, PP2A-PR55B, PP2AB-BETA, PP2APR55-BETA, PR2AB-BETA, PR2AB55-BETA, PR2APR55-BETA, PR52B, PR55-BETA, SCA12
Gene Description
protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform
Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12. [provided by RefSeq
Other Designations
PP2A, subunit B, B-beta isoform|PP2A, subunit B, R2-beta isoform|beta isoform of regulatory subunit B55, protein phosphatase 2|protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform|serine/threonine protein phosphatase 2A, 55 kDa
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Interactome
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Pathway
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Disease
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