SIAH1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot using SIAH1 polyclonal antibody (Cat # PAB10383) at 1 ug/mL on human brain lysate (20 ug/lane).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SIAH1.
Immunogen
A synthetic peptide corresponding to human SIAH1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western blot (1 to 5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot using SIAH1 polyclonal antibody (Cat # PAB10383) at 1 ug/mL on human brain lysate (20 ug/lane).Western Blot
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Gene Info — SIAH1
Entrez GeneID
6477Gene Name
SIAH1
Gene Alias
FLJ08065, HUMSIAH, Siah-1, Siah-1a, hSIAH1
Gene Description
seven in absentia homolog 1 (Drosophila)
Omim ID
602212Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq
Other Designations
seven in absentia homolog 1|sonic hedgehog homolog
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Interactome
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Pathway
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Disease
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Publication Reference
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Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins.
Hu G, Fearon ER.
Molecular and Cellular Biology 1999 Jan; 19(1):724.
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p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.
Matsuzawa S, Takayama S, Froesch BA, Zapata JM, Reed JC.
The EMBO Journal 1998 May; 17(10):2736.
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Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.
Hu G, Zhang S, Vidal M, Baer JL, Xu T, Fearon ER.
Genes & Development 1997 Oct; 11(20):2701.
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Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins.
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