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Last updated: 2016/12/4
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BAG4 polyclonal antibody

  • Catalog # : PAB10362
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of BAG4.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids 2-16 of human BAG4.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • Western blot (0.25 to 1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis using BAG4 polyclonal antibody (Cat # PAB10362) on HeLa (lanes 1, 3) and THP-1 (lanes 2, 4) whole cell lysates in the absense (lanes 1, 2) and presense (lanes 3, 4) of blocking peptide.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 9530
  • Gene Name:
  • BAG4
  • Gene Alias:
  • BAG-4,SODD
  • Gene Description:
  • BCL2-associated athanogene 4
  • Gene Summary:
  • The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. [provided by RefSeq
  • Other Designations:
  • BAG-family molecular chaperone regulator-4,silencer of death domains
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