S1PR5 polyclonal antibody
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis using S1PR5 polyclonal antibody (Cat # PAB10361) on McA-RH7777 cell lysates transfected with full length human EDG8 (lane 1) and blocked with blocking peptide (lane 2).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of S1PR5.
Immunogen
A synthetic peptide corresponding to C-terminus of human S1PR5.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western blot (5 to 10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis using S1PR5 polyclonal antibody (Cat # PAB10361) on McA-RH7777 cell lysates transfected with full length human EDG8 (lane 1) and blocked with blocking peptide (lane 2). -
Gene Info — S1PR5
Entrez GeneID
53637Gene Name
S1PR5
Gene Alias
EDG8, Edg-8, S1P5, SPPR-1, SPPR-2
Gene Description
sphingosine-1-phosphate receptor 5
Omim ID
605146Gene Ontology
HyperlinkGene Summary
The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM
Other Designations
endothelial differentiation, sphingolipid G-protein-coupled receptor, 8|sphingosine 1-phosphate receptor 5|sphingosine 1-phosphate receptor Edg-8
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Interactome
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Pathway
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Disease
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Publication Reference
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Sphingosine 1-phosphate signalling in mammalian cells.
Pyne S, Pyne NJ.
The Biochemical Journal 2000 Jul; 349(Pt 2):385.
Application：WB-Tr, Rat, Rh7777 cells.
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Characterization of a novel sphingosine 1-phosphate receptor, Edg-8.
Im DS, Heise CE, Ancellin N, O'Dowd BF, Shei GJ, Heavens RP, Rigby MR, Hla T, Mandala S, McAllister G, George SR, Lynch KR.
The Journal of Biological Chemistry 2000 May; 275(19):14281.
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Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors.
Hla T, Lee MJ, Ancellin N, Thangada S, Liu CH, Kluk M, Chae SS, Wu MT.
Annals of the New York Academy of Sciences 2000 Apr; 905:16.
Application：WB, Human, Mouse, Mammalian cells.
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Sphingosine 1-phosphate signalling in mammalian cells.
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