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Last updated: 2016/10/16
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NCOA3 polyclonal antibody

  • Catalog # : PAB10282
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of NCOA3.
  • Immunogen:
  • A synthetic peptide corresponding to internal region of human NCOA3.
  • Host:
  • Rabbit
  • Reactivity:
  • Bovine, Dog, Human, Macaque, Mouse, Rat
  • Specificity:
  • This antibody reacts with several isoforms of human NCOA3 protein (a, b, d, e and f).
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • ELISA (1:175000)
    Western Blot (1:500-1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot
  • Western Blot
  • Western blot using NCOA3 polyclonal antibody (Cat # PAB10282) shows detection of NCOA3 in mouse liver nuclear extract (lane 1), transient transfected 293 cell lysate (lane 2), HeLa whole cell lysate (lane 3) and mouse thyroid cell nuclear extract (lane 4).
    The band at ~ 148 kDa, indicated by the arrowhead, corresponds to NCOA3.
    Mouse NCOA3 (lanes 1 and 4) appear as ~ 105 kDa bands.
    Pre-incubation of antibody with the immunizing peptide blocks detection of specific band staining (not shown).
    Personal communication, H. Ying, NCI, Bethesda, MD.
  • Immunoprecipitation
  • Application Image
  • Immunoprecipitation
  • Gene Information
  • Entrez GeneID:
  • 8202
  • Protein Accession#:
  • NP_858045;Q9Y6Q9
  • Gene Name:
  • NCOA3
  • Gene Alias:
  • Gene Description:
  • nuclear receptor coactivator 3
  • Gene Summary:
  • The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq
  • Other Designations:
  • CBP-interacting protein,OTTHUMP00000031716,OTTHUMP00000031718,amplified in breast cancer-1,receptor-associated coactivator 3,steroid receptor coactivator protein 3,thyroid hormone receptor activator molecule 1
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