TP53I3 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot using TP53I3 polyclonal antibody (Cat # PAB10164) on RKO cells transfected with TP53I3 without insert (lane 1), transfected with pCEP4-TP53I3 (lane 2), under control conditions (lane3) and treated with adriamycin to activate wild-type p53 (lane 4). Also used on MCF-7 cells transfected with pCEP4 without insert (lane 5) and pCEP4-TP53I3 (lane 6).
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Specification
Product Description
Rabbit polyclonal antibody raised against full length recombinant TP53I3.
Immunogen
Recombinant protein corresponding to full length TP53I3.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot using TP53I3 polyclonal antibody (Cat # PAB10164) on RKO cells transfected with TP53I3 without insert (lane 1), transfected with pCEP4-TP53I3 (lane 2), under control conditions (lane3) and treated with adriamycin to activate wild-type p53 (lane 4). Also used on MCF-7 cells transfected with pCEP4 without insert (lane 5) and pCEP4-TP53I3 (lane 6). -
Gene Info — TP53I3
Entrez GeneID
9540Gene Name
TP53I3
Gene Alias
PIG3
Gene Description
tumor protein p53 inducible protein 3
Omim ID
605171Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000116037|p53-induced gene 3 protein|quinone oxidoreductase homolog
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Interactome
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Pathway
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Disease
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Publication Reference
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p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest.
Flatt PM, Polyak K, Tang LJ, Scatena CD, Westfall MD, Rubinstein LA, Yu J, Kinzler KW, Vogelstein B, Hill DE, Pietenpol JA.
Cancer Letters 2000 Aug; 156(1):63.
Application：IF, WB-Ce, WB-Tr, Human, Fibroblasts, Keratinocytes, MCF-10A, HCT116, RKO, HIp53, HIO, MCF-7 cells.
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Regulation of p53 downstream genes.
el-Deiry WS.
Seminars in Cancer Biology 1998 Sep; 8(5):345.
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The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression.
Venot C, Maratrat M, Dureuil C, Conseiller E, Bracco L, Debussche L.
The EMBO Journal 1998 Aug; 17(16):4668.
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p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest.
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