Western blot analysis using SRC (phospho Y529) polyclonal antibody (Cat # PAB10162) on CEF cells untransfected (lane 1) or transfeceted with wild-type human SRC (lanes 2-5). Antibody was incubated prior to use with no peptide (lanes 1, 2), non-phosphorylated immunogen peptide (lane 3), generic phosphotyrosine containing peptide (lane 4), or phosphorylated immunogen peptide (lane 5).
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq