TP73 polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against partial recombinant TP73.
Immunogen
Recombinant GST fusion protein corresponding to C-terminus of TP73.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western blot (5 to 10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunoprecipitation
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Gene Info — TP73
Entrez GeneID
7161Gene Name
TP73
Gene Alias
P73
Gene Description
tumor protein p73
Omim ID
601990Gene Ontology
HyperlinkGene Summary
This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000000662|p53-like transcription factor|p53-related protein
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Interactomes
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Pathways
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Diseases
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Publication Reference
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p300 does not require its acetylase activity to stimulate p73 function.
Zeng X, Lee H, Zhang Q, Lu H.
The Journal of Biological Chemistry 2001 Jan; 276(1):48.
Application:EMSA, WB-Ce, WB-Tr, Human, H1299 cells.
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The large T antigen of simian virus 40 binds and inactivates p53 but not p73.
Dobbelstein M, Roth J.
The Journal of General Virology 1998 Dec; 79 ( Pt 12):3079.
Application:IF, Human, Saos-2 cells.
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The potential tumor suppressor p73 differentially regulates cellular p53 target genes.
Zhu J, Jiang J, Zhou W, Chen X.
Cancer Research 1998 Nov; 58(22):5061.
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p300 does not require its acetylase activity to stimulate p73 function.
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