NUMB polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot using NUMB polyclonal antibody (Cat # PAB10143) on human brain lysate. Lysate used at 14 ug/lane. Antibody used at 10 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NUMB.
Immunogen
A synthetic peptide corresponding to human NUMB.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western blot (1 to 5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot using NUMB polyclonal antibody (Cat # PAB10143) on human brain lysate. Lysate used at 14 ug/lane. Antibody used at 10 ug/mL .Western Blot
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Gene Info — NUMB
Entrez GeneID
8650Gene Name
NUMB
Gene Alias
S171
Gene Description
numb homolog (Drosophila)
Omim ID
603728Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
numb homolog
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Interactome
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Pathway
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Disease
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Publication Reference
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Siah-1 binds and regulates the function of Numb.
Susini L, Passer BJ, Amzallag-Elbaz N, Juven-Gershon T, Prieur S, Privat N, Tuynder M, Gendron MC, Israel A, Amson R, Oren M, Telerman A.
Proc Natl Acad Sci U S A 2001 Dec; 98(26):15067.
Application：IP, WB-Ce, WB-Tr, Human, HEK 293T, Jurkat, U-937 cells.
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Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage.
Verdi JM, Bashirullah A, Goldhawk DE, Kubu CJ, Jamali M, Meakin SO, Lipshitz HD.
PNAS 1999 Aug; 96(18):10472.
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Siah-1 binds and regulates the function of Numb.
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