NSMAF polyclonal antibody
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More Files
- More Functions
Western Blot
Western blot using NSMAF polyclonal antibody (Cat # PAB10142) on human brain lysate (lane 1) and RMS-13 rhabdosarcoma cell lysate (lane 2). Lysate used at 15 ug/lane. Antibody used at 1:400 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NSMAF.
Immunogen
A synthetic peptide corresponding to human NSMAF.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western blot (1 to 5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot using NSMAF polyclonal antibody (Cat # PAB10142) on human brain lysate (lane 1) and RMS-13 rhabdosarcoma cell lysate (lane 2). Lysate used at 15 ug/lane. Antibody used at 1:400 dilution. -
Gene Info — NSMAF
Entrez GeneID
8439Gene Name
NSMAF
Gene Alias
FAN
Gene Description
neutral sphingomyelinase (N-SMase) activation associated factor
Omim ID
603043Gene Ontology
HyperlinkGene Summary
This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants
Other Designations
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Interactome
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Disease
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Publication Reference
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Factor associated with neutral sphingomyelinase activation and its role in cardiac cell death.
O'Brien NW, Gellings NM, Guo M, Barlow SB, Glembotski CC, Sabbadini RA.
Circulation Research 2003 Apr; 92(6):589.
Application：IF, IEM, Rat, Cardiomyocytes, Cardiac.
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CD40 signals apoptosis through FAN-regulated activation of the sphingomyelin-ceramide pathway.
Segui B, Andrieu-Abadie N, Adam-Klages S, Meilhac O, Kreder D, Garcia V, Bruno AP, Jaffrezou JP, Salvayre R, Kronke M, Levade T.
The Journal of Biological Chemistry 1999 Dec; 274(52):37251.
Application：WB-Ce, Human, Human lymphoid cells.
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FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase.
Adam-Klages S, Adam D, Wiegmann K, Struve S, Kolanus W, Schneider-Mergener J, Kronke M.
Cell 1996 Sep; 86(6):937.
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Factor associated with neutral sphingomyelinase activation and its role in cardiac cell death.
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