CHRM3 polyclonal antibody (Cat # PAB10136) staining of formallin fixed paraffin embedded human heart tissue at adilution of 10 ug/mL . Antigen retrieval using a citrate buffer and steam/heat was utilized.
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. [provided by RefSeq