LPAR1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LPAR1.
Immunogen
A synthetic peptide corresponding to C-terminus of LPAR1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western blot (5 to 10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis using LPAR1 polyclonal antibody (Cat # PAB10126) on McA-RH7777 cells transfected with LPAR1 protein at 5 ug/mL . -
Gene Info — LPAR1
Entrez GeneID
1902Gene Name
LPAR1
Gene Alias
EDG2, GPR26, Gpcr26, LPA1, Mrec1.3, VZG1, edg-2, rec.1.3, vzg-1
Gene Description
lysophosphatidic acid receptor 1
Omim ID
602282Gene Ontology
HyperlinkGene Summary
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq
Other Designations
OTTHUMP00000021903|OTTHUMP00000021904|OTTHUMP00000021905|endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2|ventricular zone gene 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Lysophosphatidic acid receptor-selective effects on Jurkat T cell migration through a Matrigel model basement membrane.
Zheng Y, Kong Y, Goetzl EJ.
The Journal of Immunology 2001 Feb; 166(4):2317.
Application:WB-Tr, Human, Jurkat-T, HTC4 cells.
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Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax.
Goetzl EJ, Kong Y, Mei B.
Journal of Immunology 1999 Feb; 162(4):2049.
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A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid.
Fukushima N, Kimura Y, Chun J.
PNAS 1998 May; 95(11):6151.
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Lysophosphatidic acid receptor-selective effects on Jurkat T cell migration through a Matrigel model basement membrane.
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