PPAP2C polyclonal antibody
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot analysis using PPAP2C polyclonal antibody (Cat # PAB10122) on vector-controlled HEK293 cells (lane 1) and HEK293 cells overexpressing PPAP2C protein (lane 2) at 1 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PPAP2C.
Immunogen
A synthetic peptide of human PPAP2C.
Host
Rabbit
Reactivity
Human
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western blot (10 to 15 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.08% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis using PPAP2C polyclonal antibody (Cat # PAB10122) on vector-controlled HEK293 cells (lane 1) and HEK293 cells overexpressing PPAP2C protein (lane 2) at 1 ug/mL . -
Gene Info — PPAP2C
Entrez GeneID
8612Gene Name
PPAP2C
Gene Alias
LPP2, PAP-2c, PAP2-g
Gene Description
phosphatidic acid phosphatase type 2C
Omim ID
607126Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
lipid phosphate phosphohydrolase 2|phosphatidic acid phosphohydrolase type 2c|type-2 phosphatidic acid phosphatase-gamma
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Interactome
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Pathway
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Disease
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Publication Reference
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Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent.
Hooks SB, Santos WL, Im DS, Heise CE, Macdonald TL, Lynch KR.
The Journal of Biological Chemistry 2001 Feb; 276(7):4611.
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Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.
Roberts R, Sciorra VA, Morris AJ.
The Journal of Biological Chemistry 1998 Aug; 273(34):22059.
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Plasma membrane fractions from rat liver contain a phosphatidate phosphohydrolase distinct from that in the endoplasmic reticulum and cytosol.
Jamal Z, Martin A, Gomez-Muñoz A, Brindley DN.
The Journal of Biological Chemistry 1991 Feb; 266(5):2988.
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Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent.
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