Western blot analysis is shown using ING1 polyclonal antibody (Cat # PAB10082) to detect with purified recombinant GST tagged human ING1b (Lane 1) and ING1c protein (Lane 2). No reactivity is seen against GST or other ING proteins (not shown). Reactivity of this polyclonal antibody is similar to the specificity of a positive control monoclonal antibody (not shown). The blot was incubated with a 1 : 1,000 dilution of the antibody at room temperature followed by detection using standard techniques. Personal communication Xiaolan Feng, U. Calgary.
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
OTTHUMP00000018703,OTTHUMP00000018704,OTTHUMP00000018705,OTTHUMP00000018706,growth inhibitor ING1,growth inhibitory protein ING1,inhibitor of growth 1,tumor suppressor ING1