HUS1B polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot using HUS1B polyclonal antibody (Cat # PAB10059) shows detection of a 36 kDa band corresponding to HUS1B in a HeLa cell lysate (arrowhead).
The staining pattern in 293 cells is less clear, showing apredominant band at 39 kDa.
Personal Communication, A-Lien Lu-Chang, U. Maryland, Baltimore, MD.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HUS1B.
Immunogen
A synthetic peptide corresponding to amino acids 104-117 of human HUS1B.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:20000-1:100000)
Western Blot (1:500-1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot using HUS1B polyclonal antibody (Cat # PAB10059) shows detection of a 36 kDa band corresponding to HUS1B in a HeLa cell lysate (arrowhead).
The staining pattern in 293 cells is less clear, showing apredominant band at 39 kDa.
Personal Communication, A-Lien Lu-Chang, U. Maryland, Baltimore, MD.Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — HUS1B
Entrez GeneID
135458Protein Accession#
Q8NHY5;NP_683762Gene Name
HUS1B
Gene Alias
MGC126746, MGC126748, RP11-532F6.1
Gene Description
HUS1 checkpoint homolog b (S. pombe)
Omim ID
609713Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. [provided by RefSeq
Other Designations
HUS1 checkpoint protein B|OTTHUMP00000114799
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Interactome
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Disease
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Publication Reference
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Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue.
Hopkins KM, Wang X, Berlin A, Hang H, Thaker HM, Lieberman HB.
Cancer Research 2003 Sep; 63(17):5291.
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Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1.
Hang H, Zhang Y, Dunbrack RL Jr, Wang C, Lieberman HB.
Genomics 2002 Apr; 79(4):487.
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Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue.
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