CAND2 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CAND2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 1130-1143 of human CAND2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000-1:10000)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In antiserum (0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — CAND2
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Interactome
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Disease
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Publication Reference
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Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1.
Oshikawa K, Matsumoto M, Yada M, Kamura T, Hatakeyama S, Nakayama KI.
Biochemical and Biophysical Research Communications 2003 Apr; 303(4):1209.
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CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.
Zheng J, Yang X, Harrell JM, Ryzhikov S, Shim EH, Lykke-Andersen K, Wei N, Sun H, Kobayashi R, Zhang H.
Molecular Cell 2002 Dec; 10(6):1519.
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NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases.
Liu J, Furukawa M, Matsumoto T, Xiong Y.
Molecular Cell 2002 Dec; 10(6):1511.
Application:WB-Tr, Human, HEK 293T cells.
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Multiple mammalian proteasomal ATPases, but not proteasome itself, are associated with TATA-binding protein and a novel transcriptional activator, TIP120.
Makino Y, Yoshida T, Yogosawa S, Tanaka K, Muramatsu M, Tamura TA.
Genes to Cells 1999 Sep; 4(9):529.
Application:WB-Ti, Rat, Rat livers.
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Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1.
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