AURKB polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of AURKB.
Immunogen
A synthetic peptide corresponding to amino acids 227-238 of human AURKB.
Host
Rabbit
Reactivity
Bovine, Chimpanzee, Dog, Human, Mouse, Pig, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:5000-1:20000)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
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Gene Info — AURKB
Entrez GeneID
9212Protein Accession#
Q96GD4;NP_004208Gene Name
AURKB
Gene Alias
AIK2, AIM-1, AIM1, ARK2, AurB, IPL1, STK12, STK5
Gene Description
aurora kinase B
Omim ID
604970Gene Ontology
HyperlinkGene Summary
Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004 [PubMed 14767480]).[supplied by OMIM
Other Designations
aurora-1|aurora-B|serine/threonine kinase 12
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Interactome
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Disease
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Publication Reference
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Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2.
Gruneberg U, Neef R, Honda R, Nigg EA, Barr FA.
The Journal of Cell Biology 2004 Jul; 166(2):167.
Application：IF, WB, Human, HeLa, U-2 OS cells.
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Cell cycle-dependent regulation of the human aurora B promoter.
Kimura M, Uchida C, Takano Y, Kitagawa M, Okano Y.
Biochemical and Biophysical Research Communications 2004 Apr; 316(3):930.
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Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis.
Yasui Y, Urano T, Kawajiri A, Nagata K, Tatsuka M, Saya H, Furukawa K, Takahashi T, Izawa I, Inagaki M.
The Journal of Biological Chemistry 2004 Jan; 279(13):12997.
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Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2.
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