GSK3A polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GSK3A.
Immunogen
A synthetic peptide corresponding to amino acids 16-25 of human GSK3A.
Host
Rabbit
Reactivity
Chimpanzee, Human, Rat
Specificity
This antibody will react with both the phosphorylated and non-phosphorylated form of the protein at the S21 residue. No cross reactivity is expected against GSK3B.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:4000-1:16000)
Western Blot (1:500-1:3000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
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Gene Info — GSK3A
Entrez GeneID
2931Protein Accession#
P49840;NP_063937Gene Name
GSK3A
Gene Alias
DKFZp686D0638
Gene Description
glycogen synthase kinase 3 alpha
Omim ID
606784Gene Ontology
HyperlinkGene Summary
Glycogen synthase kinase 3-alpha (GSK3A; EC {2.7.1.37}) is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase (see GYS1, {138570}) and transcription factors (e.g., JUN, {165160}). It also plays a role in the WNT ({164820}) and PI3K (see PIK3CG, {601232}) signaling pathways (see review by {1:Ali et al. (2001)}).[supplied by OMIM
Other Designations
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Pathway
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Publication Reference
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The primary defect in glycogen synthase activity is not based on increased glycogen synthase kinase-3alpha activity in diabetic myotubes.
Gaster M, Brusgaard K, Handberg A, Højlund K, Wojtaszewski JF, Beck-Nielsen H.
Biochemical and Biophysical Research Communications 2004 Jul; 319(4):1235.
Application：ELISA, KA, WB, Human, Human satellite cell cultures.
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Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function?
Barry FA, Graham GJ, Fry MJ, Gibbins JM.
FEBS Letters 2003 Oct; 553(1-2):173.
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Inhibition of glycogen synthase kinase 3 improves insulin action and glucose metabolism in human skeletal muscle.
Nikoulina SE, Ciaraldi TP, Mudaliar S, Carter L, Johnson K, Henry RR.
Diabetes 2002 Jul; 51(7):2190.
Application：WB-Ce, Human, Human skeletal muscle cell.
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The primary defect in glycogen synthase activity is not based on increased glycogen synthase kinase-3alpha activity in diabetic myotubes.
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