FKBP8 polyclonal antibody
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More Files
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Western Blot
Western blot using FKBP8 polyclonal antibody (Cat # PAB10013) shows detection of exogenous FKBP8 in 50 ug of HEK293T whole cell lysate (Lane 1).
The results of peptide competition are shown in lane 2 where no specific staining is noted after the antibody is first incubated for 1h with the immunizing peptide in 5% BLOTTO prior to reaction with the membrane.
The membrane was probed with the primary antibody at a 1 : 1,000 dilution in 5% BLOTTO at 4°C, overnight.
Personal Communication, Olga Aprelikova, CCR-NCI, Bethesda, MD.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of FKBP8.
Immunogen
A synthetic peptide corresponding to internal region of human FKBP8.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:25000)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot using FKBP8 polyclonal antibody (Cat # PAB10013) shows detection of exogenous FKBP8 in 50 ug of HEK293T whole cell lysate (Lane 1).
The results of peptide competition are shown in lane 2 where no specific staining is noted after the antibody is first incubated for 1h with the immunizing peptide in 5% BLOTTO prior to reaction with the membrane.
The membrane was probed with the primary antibody at a 1 : 1,000 dilution in 5% BLOTTO at 4°C, overnight.
Personal Communication, Olga Aprelikova, CCR-NCI, Bethesda, MD.Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — FKBP8
Entrez GeneID
23770Protein Accession#
NP_036313;Q86YK6Gene Name
FKBP8
Gene Alias
FKBP38, FKBPr38
Gene Description
FK506 binding protein 8, 38kDa
Omim ID
604840Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq
Other Designations
FK506 binding protein 8 (38kD)|FK506-binding protein 8|FK506-binding protein 8 (38kD)
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Interactome
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Publication Reference
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Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression.
Portier BP, Taglialatela G.
The Journal of Biological Chemistry 2006 Dec; 281(52):40493.
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Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90.
Okamoto T, Nishimura Y, Ichimura T, Suzuki K, Miyamura T, Suzuki T, Moriishi K, Matsuura Y.
The EMBO Journal 2006 Oct; 25(20):5015.
Application：IP, WB, Human, HEK 293T cells.
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Hepatitis C virus non-structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells.
Wang J, Tong W, Zhang X, Chen L, Yi Z, Pan T, Hu Y, Xiang L, Yuan Z.
FEBS Letters 2006 Aug; 580(18):4392.
Application：WB-Tr, Monkey, COS-7, Huh7 cells.
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Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression.
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