Western blot using FKBP8 polyclonal antibody (Cat # PAB10013) shows detection of exogenous FKBP8 in 50 ug of HEK293T whole cell lysate (Lane 1). The results of peptide competition are shown in lane 2 where no specific staining is noted after the antibody is first incubated for 1h with the immunizing peptide in 5% BLOTTO prior to reaction with the membrane. The membrane was probed with the primary antibody at a 1 : 1,000 dilution in 5% BLOTTO at 4°C, overnight. Personal Communication, Olga Aprelikova, CCR-NCI, Bethesda, MD.
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq
FK506 binding protein 8 (38kD),FK506-binding protein 8,FK506-binding protein 8 (38kD)