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Last updated: 2017/11/19
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FANCF polyclonal antibody

  • Catalog # : PAB10011
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of FANCF.
  • Immunogen:
  • A synthetic peptide corresponding to internal region of human FANCF.
  • Host:
  • Rabbit
  • Reactivity:
  • Chimpanzee, Human
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • ELISA (1:15000-1:60000)
    Western Blot (1:1000-1:5000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot using FANCF polyclonal antibody (Cat # PAB10011) shows detection of FANCF present in a lysate prepared from a Fanconi anemia complementation group F patient lymphoblast after retroviral correction using hFANCF cDNA (lanes 3 and 4).
    This band (indicated by arrowhead) is approximately 42.3 kDa in size.
    The band is not detected in FA-F a lymphoblast lysate that is not corrected for the deletion and does not express the FANCF protein (lanes 1 and 2).
    Lanes 2 and 4 represent lysates taken from lymphoblasts after 40 J/m2 UV irradiation, whereas lanes 1 and 3 received no irradiation.
    No apparent difference was noted upon irradiation.
    The strong band at ~60kDa appears to be non-specific.
    Personal communication, N. Howlett, University of Rhode Island, Kingston, RI.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 2188
  • Protein Accession#:
  • NP_073562;Q9NPI8;Q52LM0
  • Gene Name:
  • Gene Alias:
  • FAF,MGC126856
  • Gene Description:
  • Fanconi anemia, complementation group F
  • Gene Summary:
  • The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F. [provided by RefSeq
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