Western blot using DRAM polyclonal antibody (Cat # PAB10001) shows detection of a predominant band at ~33 kDa corresponding to DRAM (arrowhead) in K-562 whole cell lysate. The predicted MW of DRAM is 26 kDa. DRAM was detected using 0.5 ug/mL (lane A), 1.0 ug/mL (lane B) and 2 ug/mL (lane C) concentrations of primary antibody.
This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq