SIRT1 polyclonal antibody
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More Files
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Western Blot
Western blot analysis of SIRT1 polyclonal antibody (Cat # PAB0875) expression in Hela (A) and Hela + CoC12 (B) whole cell lysates.
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Specification
Product Description
Rabbit polyclonal antibody raised against a synthetic peptide of SIRT1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human SIRT1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1:400)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% gelatin, 0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
ChIP
Western Blot
Western blot analysis of SIRT1 polyclonal antibody (Cat # PAB0875) expression in Hela (A) and Hela + CoC12 (B) whole cell lysates. -
Gene Info — SIRT1
Entrez GeneID
23411Gene Name
SIRT1
Gene Alias
SIR2L1
Gene Description
sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
Omim ID
604479Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
OTTHUMP00000019691|OTTHUMP00000060745|SIR2alpha|sir2-like 1|sirtuin 1|sirtuin type 1
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Interactome
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Disease
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Publication Reference
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A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing.
Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, Mohammad HP, Chen W, Daniel VC, Yu W, Berman DM, Jenuwein T, Pruitt K, Sharkis SJ, Watkins DN, Herman JG, Baylin SB.
Nature Genetics 2007 Jan; 39(2):237.
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Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation.
Pruitt K, Zinn RL, Ohm JE, McGarvey KM, Kang SH, Watkins DN, Herman JG, Baylin SB.
PLoS Genetics 2006 Mar; 2(3):e40.
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A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing.
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