NFKB1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against a synthetic peptide of NFKB1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human NFKB1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody reacts with NFkB p50 and p105.
Form
Liquid
Recommend Usage
Western Blot (1:400)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% gelatin, 0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of NFKB1 polyclonal antibody (Cat # PAB0837) expression in HeLa (A) and HL-60 (B) whole cell lysates. -
Gene Info — NFKB1
Entrez GeneID
4790Gene Name
NFKB1
Gene Alias
DKFZp686C01211, EBP-1, KBF1, MGC54151, NF-kappa-B, NFKB-p105, NFKB-p50, p105, p50
Gene Description
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Omim ID
164011Gene Ontology
HyperlinkGene Summary
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
DNA binding factor KBF1|NF-kappabeta|nuclear factor NF-kappa-B p50 subunit|nuclear factor kappa-B DNA binding subunit|nuclear factor kappa-B, subunit 1
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Interactome
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Pathway
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Disease
- Abortion
- Acute Lung Injury
- Adenocarcinoma
- Alcoholism
- Alzheimer disease
- Arthritis
- Asthma
- Atherosclerosis
- Behcet Syndrome
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Publication Reference
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Enhancement of NF-kappaB expression and activity upon differentiation of human embryonic stem cell line SNUhES3.
Kang HB, Kim YE, Kwon HJ, Sok DE, Lee Y.
Stem Cells and Development 2007 Aug; 16(4):615.
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Differential effects of IL-15 and IL-21 in myeloid (CD11b+) and lymphoid (CD11b-) bone marrow cells.
Pelletier M, Girard D.
Journal of Immunology 2006 Jul; 177(1):100.
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Lack of consensus gene expression changes associated with radiation-induced chromosomal instability.
Snyder AR, Morgan WF.
DNA Repair 2005 Aug; 4(9):958.
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Enhancement of NF-kappaB expression and activity upon differentiation of human embryonic stem cell line SNUhES3.
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