RELA polyclonal antibody
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More Files
- More Functions
Western Blot
Western blot analysis of RELA polyclonal antibody (Cat # PAB0836) expression in A-431 (A) and HeLa (B) whole cell lysates.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human diffuse large B-cell lymphoma (DLBCL) showing nuclear expression of RELA in the tumor cells.
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Specification
Product Description
Rabbit polyclonal antibody raised against a synthetic peptide of RELA.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human RELA.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1:400-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% gelatin, 0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of RELA polyclonal antibody (Cat # PAB0836) expression in A-431 (A) and HeLa (B) whole cell lysates.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human diffuse large B-cell lymphoma (DLBCL) showing nuclear expression of RELA in the tumor cells. -
Gene Info — RELA
Entrez GeneID
5970Gene Name
RELA
Gene Alias
MGC131774, NFKB3, p65
Gene Description
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Omim ID
164014Gene Ontology
HyperlinkGene Summary
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM
Other Designations
nuclear factor of kappa light polypeptide gene enhancer in B-cells 3|v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65))|v-rel reticuloendotheliosis viral oncogene homolog
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Interactome
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Pathway
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Disease
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Publication Reference
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Enhancement of NF-kappaB expression and activity upon differentiation of human embryonic stem cell line SNUhES3.
Kang HB, Kim YE, Kwon HJ, Sok DE, Lee Y.
Stem Cells and Development 2007 Aug; 16(4):615.
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Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage.
Fan Z, Soder S, Oehler S, Fundel K, Aigner T.
The American Journal of Pathology 2007 Jul; 171(3):938.
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Direct role of NF-kappaB activation in Toll-like receptor-triggered HLA-DRA expression.
Lee KW, Lee Y, Kim DS, Kwon HJ.
European Journal of Immunology 2006 Apr; 36(5):1254.
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Enhancement of NF-kappaB expression and activity upon differentiation of human embryonic stem cell line SNUhES3.
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