STAT2 polyclonal antibody
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More Files
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Western Blot
Western blot analysis of STAT2 polyclonal antibody (Cat # PAB0831) in expression in A-431 (A) and HeLa (B) whole cell lysates.
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Specification
Product Description
Rabbit polyclonal antibody raised against a synthetic peptide of STAT2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human STAT2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% gelatin, 0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of STAT2 polyclonal antibody (Cat # PAB0831) in expression in A-431 (A) and HeLa (B) whole cell lysates. -
Gene Info — STAT2
Entrez GeneID
6773Gene Name
STAT2
Gene Alias
ISGF-3, MGC59816, P113, STAT113
Gene Description
signal transducer and activator of transcription 2, 113kDa
Omim ID
600556Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. [provided by RefSeq
Other Designations
interferon alpha induced transcriptional activator|signal transducer and activator of transcription 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Upregulation of a small subset of genes drives type I interferon-induced antiviral memory.
Jaitin DA, Schreiber G.
Journal of Interferon & Cytokine Research: the Official Journal of the International Society for Int 2007 Sep; 27(8):653.
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Upregulation of a small subset of genes drives type I interferon-induced antiviral memory.
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