CASP1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against a synthetic peptide of CASP1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human CASP1.
Host
Rabbit
Reactivity
Human
Specificity
This antibody reacts with human caspase-1 precursor (also designated ICE), non cross-reactive with caspase-1 p10 or caspase-1 p20.
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.2% gelatin, 0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Human caspase-1 precursor (also designated ICE) , non cross-reactive with caspase-1 p10 or caspase-1 p20. -
Gene Info — CASP1
Entrez GeneID
834Gene Name
CASP1
Gene Alias
ICE, IL1BC, P45
Gene Description
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Omim ID
147678Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
CASP1 nirs variant 1|IL1B-convertase|caspase 1|caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)|interleukin 1-B converting enzyme|interleukin 1-beta convertase
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