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Last updated: 2016/12/4
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SNCA polyclonal antibody

  • Catalog # : PAB0770
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  • Specification
  • Product Description:
  • Sheep polyclonal antibody raised against synthetic peptide of SNCA.
  • Immunogen:
  • A synthetic peptide (conjugated diphtheria toxoid) corresponding to amino acids 108-120 of human SNCA.
  • Sequence:
  • PQEGILEDMPVDPC
  • Host:
  • Sheep
  • Reactivity:
  • Human, Rat
  • Specificity:
  • Immunihistochemical analysis of human and rat brain indicates a high level of specificity for this antiserum. Specificity was also confirmed by western blot.
  • Form:
  • Lyophilized
  • Recommend Usage:
  • Immunohistochemistry (1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from PBS
  • Storage Instruction:
  • Store at 4°C on dry atmosphere.
    After reconstitution with deionized water, store at -20°C or lower.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (paraffin - emedded tissue) of SNCA in human neocortex using sheep SNCA polyclonal antibody (Cat # PAB0770) .
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical staining (paraffin - emedded tissue) of glial inclusions in white matter from a case of multiple system atrophy using sheep SNCA polyclonal antibody (Cat # PAB0770).
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 6622
  • Gene Name:
  • SNCA
  • Gene Alias:
  • MGC110988,NACP,PARK1,PARK4,PD1
  • Gene Description:
  • synuclein, alpha (non A4 component of amyloid precursor)
  • Gene Summary:
  • Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000161559,OTTHUMP00000161561,alpha synuclein,alpha-synuclein,alpha-synuclein, isoform NACP140,non A-beta component of AD amyloid,non A4 component of amyloid
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