SNCA polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (paraffin - embedded tissue) of glial inclusions in white matter from a case of multiple system atrophy using sheep SNCA polyclonal antibody (Cat # PAB0767).
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Specification
Product Description
Sheep polyclonal antibody raised against synthetic peptide of SNCA.
Immunogen
A synthetic peptide (conjugated diphtheria toxoid) corresponding to amino acids 116-131 of human SNCA.
Sequence
CMPVDPDNEAYEMPSEE
Host
Sheep
Reactivity
Human, Mouse, Rat
Specificity
This antiserum specifically detects alpha synuclein.
Form
Lyophilized
Recommend Usage
Immunohistochemistry (1 ug/mL)
Western Blot (0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS
Storage Instruction
Store at 4°C on dry atmosphere.
After reconstitution with deionized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (paraffin - embedded tissue) of glial inclusions in white matter from a case of multiple system atrophy using sheep SNCA polyclonal antibody (Cat # PAB0767).Enzyme-linked Immunoabsorbent Assay
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Gene Info — SNCA
Entrez GeneID
6622Protein Accession#
P37840Gene Name
SNCA
Gene Alias
MGC110988, NACP, PARK1, PARK4, PD1
Gene Description
synuclein, alpha (non A4 component of amyloid precursor)
Gene Ontology
HyperlinkGene Summary
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000161559|OTTHUMP00000161561|alpha synuclein|alpha-synuclein|alpha-synuclein, isoform NACP140|non A-beta component of AD amyloid|non A4 component of amyloid
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Interactome
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Disease
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