Western blot detection of recombinant SUMO1 protein using sheep SUMO1 polyclonal antibody (Cat # PAB0765) at a dilution of 1 : 8000. The protein sample was 1 uL of E.Coli cell lysate containing approximately 50 ng of recombinant SUMO1 protein. This antibody recognises a major band of approximately 17 KDa corresponding to SUMO1, as well as a smaller minor band of 8 KDa.
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq
GAP modifying protein 1,SMT3 suppressor of mif two 3 homolog 1,sentrin,ubiquitin-like 1 (sentrin)