GFRA2 polyclonal antibody
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More Files
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Immunohistochemistry
Immunohistochemical staining of rat dorsal root ganglia using rabbit GFRA2 polyclonal antibody (Cat # PAB0694) .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GFRA2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 376-390 of human GFRA2.
Sequence
PRVEKTPSLPDDLSD
Host
Rabbit
Reactivity
Human, Rat
Form
Lyophilized
Recommend Usage
Immunohistochemistry (1:500-1:1000)
Western Blot (1:500-1:1000)
The optimal dilution should be determined by the end user.Storage Buffer
Lyophilized from whole serum.
Storage Instruction
Store at 4°C for short term. For long term storage, store at -20°C on dry atmosphere.
After reconstitution with 100 uL of sterile water, store at -20°C. Centrifuge to remove any insoluble material. Or at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
Immunohistochemical staining of rat dorsal root ganglia using rabbit GFRA2 polyclonal antibody (Cat # PAB0694) . -
Gene Info — GFRA2
Entrez GeneID
2675Protein Accession#
O00451Gene Name
GFRA2
Gene Alias
GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2
Gene Description
GDNF family receptor alpha 2
Omim ID
601956Gene Ontology
HyperlinkGene Summary
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
GFR-alpha 2|PI-linked cell-surface accessory protein|RET ligand 2|TGF-beta related neurotrophic factor receptor 2|TRN receptor, GPI-anchored|glial cell line derived neurotrophic factor receptor, beta|glial cell line-derived neurotrophic factor family rece
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Interactome
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Disease
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