Products

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with ESPL1 (phospho S1126) polyclonal antibody (Cat # PAB0608) which was peroxidase-conjugated to the secondary antibody followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma.

Dot Blot (Peptide)

Dot blot analysis of ESPL1 (phospho S1126) polyclonal antibody (Cat # PAB0608) on nitrocellulose membrane. 50 ng of nonphospho-peptide or phospho-peptide were adsorbed on their respective dots.

Entrez GeneID

9700

Protein Accession#

NP_036423;Q14674

Gene Name

ESPL1

Gene Alias

ESP1, FLJ46492, KIAA0165, SEPARASE, SEPARIN

Gene Description

extra spindle pole bodies homolog 1 (S. cerevisiae)

Omim ID

604143

Gene Ontology

Hyperlink

Gene Summary

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 604359) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM

Other Designations

extra spindle poles like 1|separin, separase