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Last updated: 2016/10/23
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MYC (phospho T58) polyclonal antibody

  • Catalog # : PAB0541
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic phosphopeptide of MYC.
  • Immunogen:
  • Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T58 of human MYC.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein A purification
  • Recommend Usage:
  • Dot Blot (1:100-500)
    Western Blot (1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of MYC (phospho T58) polyclonal antibody (Cat # PAB0541) in human TPA activated HeLa cell line lysates. Phospho-MYC (arrow) was detected using the purified PAb.
    (0: without TPA; 1: 60 ug/ml TPA, 15 min; 2: 60 ug/ml TPA, 30 min; 3: 60 ug/ml TPA, 45 min; 4: 125 ug/ml TPA, 15 min; 5: 125 ug/ml TPA, 30 min; 6: 125 ug/ml TPA, 45 min; 7: 250 ug/ml TPA, 15 min; 8: 250 ug/ml TPA, 30 min; 9: 250 ug/ml, 45 min).
  • Dot Blot (Peptide)
  • Dot Blot (Peptide)
  • Dot blot analysis of MYC (phospho T58) polyclonal antibody (Cat # PAB0541) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 4609
  • Protein Accession#:
  • NP_002458;P01106
  • Gene Name:
  • MYC
  • Gene Alias:
  • bHLHe39,c-Myc
  • Gene Description:
  • v-myc myelocytomatosis viral oncogene homolog (avian)
  • Gene Summary:
  • The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq
  • Other Designations:
  • avian myelocytomatosis viral oncogene homolog,myc proto-oncogene protein,v-myc avian myelocytomatosis viral oncogene homolog
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