MAP3K7 (phospho S192) polyclonal antibody
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More Files
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Dot Blot (Peptide)
Dot blot analysis of MAP3K7 (phospho S192) polyclonal antibody (Cat # PAB0516) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. P-Pab : phospho-antibody; P-Peptide : phospho-peptide; NP-Peptide : non-phospho-peptide.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of MAP3K7.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S192 of human MAP3K7.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Dot Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Dot Blot (Peptide)
Dot blot analysis of MAP3K7 (phospho S192) polyclonal antibody (Cat # PAB0516) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. P-Pab : phospho-antibody; P-Peptide : phospho-peptide; NP-Peptide : non-phospho-peptide. -
Gene Info — MAP3K7
Entrez GeneID
6885Protein Accession#
NP_003179;O43318Gene Name
MAP3K7
Gene Alias
TAK1, TGF1a
Gene Description
mitogen-activated protein kinase kinase kinase 7
Omim ID
602614Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
OTTHUMP00000016870|OTTHUMP00000016871|OTTHUMP00000016872|OTTHUMP00000016873|TGF-beta activated kinase 1|transforming growth factor-beta-activated kinase 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Wnt activates the Tak1/Nemo-like kinase pathway.
Smit L, Baas A, Kuipers J, Korswagen H, van de Wetering M, Clevers H.
The Journal of Biological Chemistry 2004 Feb; 279(17):17232.
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A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta.
Ono K, Ohtomo T, Ninomiya-Tsuji J, Tsuchiya M.
Biochemical and Biophysical Research Communications 2003 Jul; 307(2):332.
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Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway.
Sakurai H, Suzuki S, Kawasaki N, Nakano H, Okazaki T, Chino A, Doi T, Saiki I.
The Journal of Biological Chemistry 2003 Jul; 278(38):36916.
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Wnt activates the Tak1/Nemo-like kinase pathway.
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