DAXX (phospho S213) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of DAXX.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S213 of human DAXX.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The DAXX (phospho S213) polyclonal antibody (Cat # PAB0448) is used in Western blot to detect Phospho-DAXX-S213 in mouse thymus tissue lysateImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with DAXX (phospho S213) polyclonal antibody (Cat # PAB0448) which was peroxidase-conjugated to the secondary antibody followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma. -
Gene Info — DAXX
Entrez GeneID
1616Protein Accession#
NP_001341;Q9UER7Gene Name
DAXX
Gene Alias
BING2, DAP6, EAP1, MGC126245, MGC126246
Gene Description
death-domain associated protein
Omim ID
603186Gene Ontology
HyperlinkGene Summary
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
CENP-C binding protein|ETS1-associated protein 1|Fas-binding protein|OTTHUMP00000029289|OTTHUMP00000029290|death-associated protein 6
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Interactome
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Publication Reference
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Interaction between the human cytomegalovirus UL82 gene product (pp71) and hDaxx regulates immediate-early gene expression and viral replication.
Cantrell SR, Bresnahan WA.
Journal of Virology 2005 Jun; 79(12):7792.
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The cellular protein daxx interacts with avian sarcoma virus integrase and viral DNA to repress viral transcription.
Greger JG, Katz RA, Ishov AM, Maul GG, Skalka AM.
Journal of Virology 2005 Apr; 79(8):4610.
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Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4.
Chang CC, Lin DY, Fang HI, Chen RH, Shih HM.
The Journal of Biological Chemistry 2005 Jan; 280(11):10164.
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Interaction between the human cytomegalovirus UL82 gene product (pp71) and hDaxx regulates immediate-early gene expression and viral replication.
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