TLR7 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of TLR7 in RAW cell lysate using TLR7 polyclonal antibody (Cat # PAB0384) at 1 ug/mL .
Immunohistochemistry
Immunohistochemical analysis of human colon tissue using TLR7 polyclonal antibody (Cat # PAB0384) (top) and an isotype control (bottom) at 5 ug/mL .
Flow Cytometry
Intracellular staining by FACS analysis of TLR7 in human PBMC using TLR7 polyclonal antibody (Cat # PAB0384) at 0.5 ug/mL. Shaded histogram is cells alone, Green is rabbit IgG isotype control, red represents anti-TLR7 antibody. Imgenex Goat anti-rabbit PE was used for secondary.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TLR7.
Immunogen
A synthetic peptide corresponding to amino acids 706-728 of human TLR7.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of TLR7 in RAW cell lysate using TLR7 polyclonal antibody (Cat # PAB0384) at 1 ug/mL .Immunohistochemistry
Immunohistochemical analysis of human colon tissue using TLR7 polyclonal antibody (Cat # PAB0384) (top) and an isotype control (bottom) at 5 ug/mL .Flow Cytometry
Intracellular staining by FACS analysis of TLR7 in human PBMC using TLR7 polyclonal antibody (Cat # PAB0384) at 0.5 ug/mL. Shaded histogram is cells alone, Green is rabbit IgG isotype control, red represents anti-TLR7 antibody. Imgenex Goat anti-rabbit PE was used for secondary. -
Gene Info — TLR7
Entrez GeneID
51284Protein Accession#
AAF78035Gene Name
TLR7
Gene Alias
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Gene Description
toll-like receptor 7
Omim ID
300365Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq
Other Designations
OTTHUMP00000022919
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Interactome
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Pathway
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Disease
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Publication Reference
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Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells.
Clark RA, Huang SJ, Murphy GF, Mollet IG, Hijnen D, Muthukuru M, Schanbacher CF, Edwards V, Miller DM, Kim JE, Lambert J, Kupper TS.
The Journal of Experimental Medicine 2008 Sep; 205(10):2221.
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Antitumor effects of imidazoquinolines in urothelial cell carcinoma of the bladder.
Smith EB, Schwartz M, Kawamoto H, You X, Hwang D, Liu H, Scherr DS.
The Journal of Urology 2007 Jun; 177(6):2347.
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The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling.
Brinkmann MM, Spooner E, Hoebe K, Beutler B, Ploegh HL, Kim YM.
Journal of Cellular Biology 2007 Apr; 177(2):265.
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Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract.
Palladino MA, Johnson TA, Gupta R, Chapman JL, Ojha P.
Biology of Reproduction 2007 Jun; 76(6):958.
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Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice.
Patole PS, Pawar RD, Lech M, Zecher D, Schmidt H, Segerer S, Ellwart A, Henger A, Kretzler M, Anders HJ.
Nephrology, Dialysis, Transplantation 2006 Sep; 21(11):3062.
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Toll-like receptor-7 modulates immune complex glomerulonephritis.
Rahul D Pawar, Prashant S Patole, Daniel Zecher, Stephan Segerer, Matthias Kretzler, Detlef Schlöndorff, Hans-Joachim Anders.
Journal of the American Society of Nephrology 2006 Jan; 17(1):141.
Application：Flow Cyt, IF, IHC-P, Mouse, Mouse kidney, Mouse macrophages, Mouse mesangial cells.
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TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production.
Orla M Hart, Veronica Athie-Morales, Geraldine M O'Connor, Clair M Gardiner.
The Journal of Immunology 2005 Aug; 175(3):1636.
Application：WB-Ce, Human, 293T, NKL, NK92, YT cells.
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Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line.
Srivastava MD, Srivastava BI.
Leukemia Research 2005 Jul; 29(7):813.
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Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad.
Francois S, El Benna J, Dang PM, Pedruzzi E, Gougerot-Pocidalo MA, Elbim C.
Journal of Immunology 2005 Mar; 174(6):3633.
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Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells.
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