Western blot analysis of TLR7 in RAW cell lysate using TLR7 polyclonal antibody (Cat # PAB0384) at 1 ug/mL .
Immunohistochemical analysis of human colon tissue using TLR7 polyclonal antibody (Cat # PAB0384) (top) and an isotype control (bottom) at 5 ug/mL .
Intracellular staining by FACS analysis of TLR7 in human PBMC using TLR7 polyclonal antibody (Cat # PAB0384) at 0.5 ug/mL. Shaded histogram is cells alone, Green is rabbit IgG isotype control, red represents anti-TLR7 antibody. Imgenex Goat anti-rabbit PE was used for secondary.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq