Western blot analysis of IL24 in the A) absence and B) presence of blocking peptide in Jurkat cell lysate. Using IL24 polyclonal antibody (Cat # PAB0345) at 0.5 ug/mL .
Cell-surface flow cytometry analysis of IL24 in Jurkat cells. Using IL24 polyclonal antibody (Cat # PAB0345) at 5 ug/10^6 cells. The shaded histogram represents cells only, Green represents isotype control, and purple represents anti-IL24 antibody.
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
IL-24 splice variant delE3,IL-24 splice variant delE5,OTTHUMP00000034620,melanoma differentiation association protein 7,suppression of tumorigenicity 16 (melanoma differentiation)